Posts tagged ‘type 1 diabetes’


Diabetes research: From epigenetics to islet cell transplants

January 5, 2014 | by
Islet cells produce insulin
Nearly 350 million people worldwide are coping with diabetes, and the disease is expected to be the seventh-leading cause of death by 2030. Aware of these grim statistics, researchers at City of Hope are committed to halting the global epidemic. Researchers at City of Hope are working on multiple fronts to make islet transplantation a viable option for patients. On the frontiers of epigenetic engineering Art Riggs, Ph.D., chair of the Department of Diabetes and Metabolic Diseases Research, is focused on the possibilities within the field of epigenetics. A concept pioneered by Riggs, epigenetics refers to stable…

Meet our doctors: Endocrinologist Raynald Samoa on diabetes

October 12, 2013 | by
Raynald Samoa
City of Hope endocrinologist Raynald Samoa, M.D., has seen a lot of people struggle with their weight. His roots are in the South Pacific, a region that has eight of the 10 countries with the highest prevalence of obesity in the world, according to Forbes.com. Raynald Samoa, a City of Hope endocrinologist, says eating better and exercising can reduce the risk of type 2 diabetes. Now, as a physician, Samoa is committed to fighting obesity and its associated diseases, including diabetes. Here he offers insight into how certain lifestyle changes can make a dramatic difference in the…

Treasure islets: Pancreatic cells hold promise for diabetes

July 12, 2013 | by
The green stain on this image of a human islet cell shows insulin, while the blue spots are the nuclei of the cells, stained for DNA. (Photo Credit: Ivan Todorov)
The Islets of Langerhans may sound like an exclusive tropical retreat, but they’re closer to home than you might think. These islets are found in the pancreas and hold precious treasures for researchers bent on finding cures for diabetes. The Islets of Langerhans are clusters of cells in the pancreas, which include insulin-producing cells. In patients with type 1 diabetes, the immune system attacks and kills these cells. (Photo credit: Ivan Todorov) Commonly referred to as islets, they’re clusters of cells in the pancreas, containing 1,000 to 3,000 cells each – resembling small islands in…

Diabetes researcher’s quest: Find adult pancreatic stem cells

May 24, 2013 | by
In type 1 diabetes, insulin-producing islet cells in the pancreas are killed by the immune system. Researchers hope to use stem cells to cultivate islet cells for transplantation.
H. Teresa Ku, Ph.D., believes adult pancreatic stem cells could hold the key to making a type 1 diabetes cure more widely available. In type 1 diabetes, insulin-producing islet cells in the pancreas are killed by the immune system. Researchers hope to use stem cells to cultivate islet cells for transplantation. (Credit: Ivan Todorov) First, she has to prove they exist. Transplantation of insulin-producing islet cells into the pancreas is one promising method for treating type 1 diabetes patients, particularly those with very advanced disease that can no longer be sufficiently managed with insulin shots.…

Diabetes and islet cells: The quest for a permanent cure

March 6, 2013 | by
Pancreas, highlighted
Not all diabetes researchers are obsessed with islet cells – just many of them. And for good reason. Diabetes destroys the islet cells that produce insulin, a hormone necessary to regulate blood sugar. In diabetes, the body destroys insulin-producing cells in the pancreas, highlighted here. Researchers hope to replace those cells. Researchers at the Diabetes Research Center at City of Hope, one of the most influential diabetes research programs in the world, are working on impressive array of approaches to diabetes treatment and cure, as detailed in a previous story.  But the work on islet cells is…

Diabetes researcher’s goal: Make insulin-producing cells in lab

January 29, 2013 | by
Pancreas, highlighted
As people diagnosed with type 1 diabetes know all too well, their disease is caused by their own immune system’s destruction of insulin-producing cells in the pancreas. Treatments exist, but there is no long-term  cure. In diabetes, the body destroys insulin-producing cells in the pancreas, highlighted here. Insulin can stabilize blood sugar levels, but dosage is sometimes difficult to determine and manage, resulting in hypoglycemia. Over time, poor management of blood sugar levels can lead to kidney failure, cardiovascular disease and stroke. Because nothing is as good as one’s own cells, some City of Hope investigators…

Future of type 1 diabetes: Islet cells could hold key to a cure

December 21, 2012 | by
Islet cells produce insulin
Type 1 diabetes can be difficult to manage, and many patients need to stay vigilant about their blood sugar levels, strictly control their diet and keep insulin always close at hand to ensure that their blood glucose doesn’t soar too high or fall too low. In type 1 diabetes, insulin-producing islet cells in the pancreas are killed by the immune system. City of Hope researchers are among the scientists and physicians investigating treatments for type 1 diabetes that could ultimately bring an end to regular insulin injections, and prevent the long-term health problems associated with the…

Lower-weight pancreas could mean higher risk for type 1 diabetes

December 12, 2012 | by
3D image of translucent body showing organs and highlighted pancreas
The evidence is clear: Being overweight increases the risk of diabetes – or at least type 2 diabetes. Now new research has given an odd and unexpected twist to the connection between weight and diabetes risk – this time for the juvenile-onset version of the disease, known as type 1. In a report published today by the Journal of the American Medical Association, researchers from City of Hope and the University of Florida, Gainesville, found that people with type 1 diabetes and those at higher risk of the disease appear to have lighter-than-normal pancreases. (more…)

On World Diabetes Day, a look to the past — and the future

November 14, 2012 | by
World Diabetes Day logo
On World Diabetes Day, consider both the breakthroughs already made – and the ones yet to come. 1949 – Discovery of metabolic effects of insulin 1968 – Identifying the role of Hb-A1c in diabetes management 1978 – First engineering of human insulin in the laboratory 1982 – Isolation of specific cell proteins that join with insulin and mediate its metabolic effects All of these were accomplished by researchers affiliated with City of Hope in Duarte, Calif. Today the work to end diabetes continues. The Department of Diabetes, Endocrinology & Metabolism is currently leading a multicenter…

Can donated marrow do away with type 1 diabetes?

June 21, 2012 | by
COH
City of Hope researchers are working on a treatment for type 1 diabetes that could potentially cure the disease without toxic side effects. Defu Zeng, M.D., and his team published the latest results from their lab studies in Science Translational Medicine on May 9. He shares insights on the strategy, and why it’s important, in this short video. In type 1 diabetes, the immune system mistakenly attacks and kills beta cells, the cells in the pancreas that make insulin. And without insulin, your body can’t convert food into energy. The researchers tested a two-part strategy:…