Posts tagged ‘triple-negative breast cancer’


Using neural stem cells to sneak up on breast cancer metastases

May 3, 2013 | by
A City of Hope researcher was awarded a grant to continue collaboration on research using neural stem cells, which naturally home to cancer cells, to deliver cancer-fighting drugs.
A City of Hope researcher has been awarded a grant to use neural stem cells, which naturally home in on cancer cells (shown here), to deliver cancer-fighting drugs. Triple-negative breast cancer is both aggressive and tough to fight with existing therapies, a combination that often results in the disease’s spread; in fact, most deaths related to this form of cancer occur due to metastases. New City of Hope research is targeting these metastases specifically. Building on a platform developed at City of Hope by Karen Aboody, M.D., Rachael Mooney, Ph.D., a postdoctoral CIRM Scholar and a fellow in Aboody’s laboratory, hopes…

Scientists work across disciplines to fight breast, ovarian cancers

March 10, 2013 | by
Among the research into women's cancers at City of Hope is a study of x
The Women’s Cancers Program at City of Hope unites scientists from across disciplines who aim to prevent cancer, seek out better treatments and help survivors live whole, healthy lives. Led by Joanne Mortimer, M.D., the program strives to bring hope and healing to women fighting cancer. Here’s a snapshot of the current research efforts: Among the research into women’s cancers at City of Hope is a study by Susan L. Neuhausen of how gene mutations affect a woman’s risk of ovarian cancer and her response to treatment. Shown here: DNA strands. Predicting risk for cancer Susan L. Neuhausen, Ph.D.,…

Nanotechnology may turn stem cells into breast-cancer smart bombs

December 18, 2012 | by
stem cell research
Karen Aboody, M.D., turns neural stem cells into targeted drugs that track down and kill cancer cells. Triple-negative breast cancer is, in a way, the outlier in breast cancer research. Increasingly effective targeted treatments are now used against other breast cancers, but with no vulnerable gene target, no response to hormone therapy and a resistance to most available standard treatments, triple-negative breast cancer can be a monstrous mountain to overcome. City of Hope researchers Karen Aboody, M.D., and Jacob Berlin, Ph.D., are collaborating to develop new therapies using neural stem cells and nanoparticles. Ultimately, such…

‘My cancer diagnosis: What I wish I’d known’ – Stephanie Hosford

December 4, 2012 | by
Stephanie Hosford and family
The first in a series of stories asking former patients to reflect upon their experience… Within three days in 2007, Stephanie Hosford learned she was pregnant — and that she had triple-negative breast cancer. (Credit: City of Hope) During three turbulent days in 2007, Stephanie Hosford, then 37, learned that she was pregnant with her long-awaited second child – and that she had triple-negative breast cancer. Not long after the diagnosis, Stephanie also discovered that she and her husband, Grant, had been approved to adopt a little girl from China.  They proceeded with both plans to…

Super foods: A palatable way to defend against breast cancer

October 31, 2012 | by
Shiuan Chen in lab with mushroom
Science is proving that a trio of popular and tasty super foods could offer an effective way to prevent breast cancer. The findings are hard evidence that some foods can work against cancer. Shiuan Chen studies super foods. (Photo by Walter Urie) City of Hope’s Shiuan Chen, Ph.D., professor and chair of the Department of Cancer Biology, has studied the cancer-fighting potential of foods for decades. His early work began with mushrooms. In the years since, he’s added blueberries and pomegranates to the list. Chen has found these foods have natural chemicals that can put…

Researchers tackle cancer stem cells to counter triple-negative breast cancer

November 1, 2011 | by
George Somlo, M.D., F.A.C.P
Nearly one out of five breast cancer patients has triple-negative breast cancer — an aggressive type of tumor that often returns despite treatment. This cancer can defy conventional therapy, and breast cancer stem cells may be to blame, explains City of Hope’s George Somlo, M.D., F.A.C.P.  in this video. Somlo, co-director of City of Hope’s Breast Cancer Program, says that successful, modern therapies like Herceptin target receptors found on the surface of most breast cancer cells. But triple-negative breast cancers have none of those receptors. They can resist other drug treatments, too, because their cells…