Posts tagged ‘RLIP76’


Orange rind could aid search for anti-cancer, anti-obesity drug

July 26, 2013 | by
Researchers are interested in compounds derived from orange rinds that have the potential to inhibit a protein known as RLIP76, which has been linked to cancer and obesity.
Not only is a single protein now believed to be implicated in three of the most serious health threats today – cancer, diabetes and obesity – scientists are currently charting the course toward clinical trials targeting the protein. Researchers are interested in compounds derived from orange rinds that have the potential to inhibit a protein known as RLIP76, which has been linked to cancer and obesity. City of Hope researchers recently published a study linking the protein, known as RLIP76, and the gene that produces it directly to obesity, garnering much attention for their work.…

New study links a protein to diabetes, obesity and cancer

July 9, 2013 | by
City of Hope research has found that the protein RLIP76, modeled in above graphic, plays a significant role in weight gain, as well as controlling blood sugar, triglyceride and cholesterol levels.
A gene may play as large a role in the cause of obesity as the foods we eat, according to new research from City of Hope. City of Hope researchers found that the protein RLIP76, modeled in above graphic, plays a significant role in weight gain, as well as controlling blood sugar, triglyceride and cholesterol levels. The study, published in the Journal of Biological Chemistry, found that a protein, called RLIP76, produced by a specific gene, plays a significant role in obesity. Mice lacking the protein were resistant to gaining weight on a high-fat diet…

Pancreatic cancer: Put a cork in it

June 26, 2012 | by
Photo of kid with cork in his mouth
One of the reasons pancreatic cancer is so tough to beat is that it can survive the damage caused by radiation and chemotherapy. But City of Hope researchers figured out a way to make pancreatic cancer cells more vulnerable to therapy. They hope to push their studies into clinical trials in the near future. “Pancreatic cancer patients are a special case of the particularly unlucky, and in many ways the most miserable. The drug and radiation resistance of this cancer is legendary,” says City of Hope physician-researcher Sanjay Awasthi, M.D., who leads the effort. So…