Posts tagged ‘lymphoma’
Dave Sobel’s philosophy had always been about living life to the fullest. He loved golfing, listening to rock music and tropical relaxation. As his daughter, Lauren Miller, recalled: “His dream was to retire in the Caribbean and spend his days running a boat, a lime wedge in his tropical drink.”
Sadly, Sobel’s dream never came to fruition. In 2010, at the age of 54, his life was cut short by angioimmunoblastic T cell lymphoma, a very rare and aggressive cancer.
In honor of her father’s memory, Miller , a legal secretary, created the Slice of Lime Foundation, named after her father’s retirement dream, as well as the lime green cancer ribbon for lymphoma. Since 2010, the charity has raised more than $35,000 for blood cancer research and treatment.
Recently, to mark Slice of Lime’s fifth anniversary, Miller resolved to make a direct impact on the Simi Valley community, where her father and mother, Anita, had raised her and her siblings, and where her mother still resides today. “I wanted to do something special for Simi Valley residents,” Miller said. After some initial research, she pledged $25,000 for City of Hope’s new community clinic in Simi Valley, to be raised by Slice of Lime.
This donation is the first to be specifically designated to the Simi Valley clinic. » Continue Reading
His voice sounds distant and a bit distorted. The phone isn’t working properly. A second and third attempt to make the connection fail as well, so he patiently offers his cell phone number, not a hint of frustration apparent in his voice. The fourth time’s a charm; the connection is crystal-clear.
Larry Kwak, M.D., Ph.D., a recognized expert in the clinical management of patients with low-grade lymphomas and a highly acclaimed cancer researcher, thoughtfully answers the questions posed to him. He is careful to choose the right words, not for fear of mistakes, but to ensure his listener understands his meaning. It’s easy to see why he is beloved by patients and highly respected as a researcher.
Kwak, in fact, is world-renowned for his expertise as a translational research scientist and physician. Formerly chair of the lymphoma and myeloma department at MD Anderson Cancer Center in Houston, he recently joined City of Hope in a key leadership role within the new Hematologic Malignancies and Stem Cell Transplantation Institute. He is director of the Toni Stephenson Lymphoma Center, shaping the next generation of research and treatments for all types of lymphoma.
Bringing new therapies to patients quickly
Kwak also serves as the inaugural associate director for developmental therapeutics and translational research for the City of Hope’s comprehensive cancer center. He also is the first to hold the title of Dr. Michael Friedman Professor in Translational Medicine.
Known for his ability to bring together and lead effective research teams, he excels at integrating basic discoveries in academic laboratories with translational clinical development. » Continue Reading
Known for his ability to bring together, and lead, effective research teams, world-renowned translational research scientist and physician Larry W. Kwak, M.D., Ph.D., has joined City of Hope in a key leadership role within the institution’s new Hematologic Malignancies and Stem Cell Transplantation Institute.
As director of the Toni Stephenson Lymphoma Center, Kwak will shape the next generation of research and treatments for all types of lymphoma. Kwak also will serve as the inaugural associate director for developmental therapeutics and translational research for the comprehensive cancer center, and he is the first holder of the title of Dr. Michael Friedman Professor for Translational Medicine.
In other words, Kwak will integrate basic scientific discoveries into clinical use.
“What makes me excited to come to work every morning — my passion — is moving lab discoveries to clinic,” he said. “One of my key roles will be to help our faculty develop their ideas and bring them to first-in-human clinical trials.”
The two hadn’t been in contact with each other for some time, but McKinny couldn’t think of anyone else with whom he wanted to be during that difficult period. He knew he had to find Mullins.
That proved more challenging than McKinny had imagined. Even with the help of the Internet and social media networking sites, McKinny wasn’t able to locate and communicate with his former boyfriend.
There was little left for McKinny to do but continue with his treatment on his own, as best he could. After his doctors in Hemet, California, told him there was nothing else they could do for him, he was transferred to City of Hope. At that time, his prognosis suggested he had but two months to live. Fortunately, because of City of Hope, that prognosis proved to be too grim.
In March 2011, McKinny had a stem cell transplant at City of Hope, which gave him more time with his family and friends, not to mention additional time to find Mullins. Finally, in 2013, three years after his diagnosis, McKinny located Mullins. They connected. The two have been inseparable ever since. » Continue Reading
Geoff Berman, 61, starts his day with the motto: “The sun is up. I’m vertical. It’s a good day.”
Ever since he’s been in remission from lymphoma, Berman makes a special point of being grateful for each day, reminding himself that being alive is a gift. “I just enjoy living,” he said. “I give every ounce of positivity I can.”
This resolve followed Berman’s diagnosis for lymphoma in 2013, just days after purchasing a new home in Palm Desert, California, with his wife. They’d planned to live there peacefully and uneventfully with their two cats.
But what Berman first thought was a pulled groin turned out to be an abdominal mass the size of a grapefruit, and he was soon diagnosed with aggressive B cell non-Hodgkin lymphoma. Finally, after seven rounds of chemotherapy, Berman came to City of Hope for an autologous stem cell transplant.
Cutaneous lymphoma, a form of non-Hodgkin lymphoma, is a rare type of cancer that begins in the white blood cells and attacks the skin. It can cause rash-like skin redness and, sometimes, skin tumors. Although cutaneous lymphomas are rare, accounting for about 5 percent of all non-Hodgkin lymphomas, approximately 20,000 people in the United States are estimated to have cutaneous lymphoma.
Here, dermatologist/dermatopathologist and cutaneous lymphoma expert Christiane Querfeld, M.D., Ph.D., director of City of Hope’s Cutaneous Lymphoma Program, discusses how new therapy options and continued collaboration among physicians have contributed to better care and outcomes for cutaneous lymphoma patients, and helped many to return to a normal life.
What is cutaneous lymphoma and what causes it?
Cutaneous lymphomas, also known as lymphomas of the skin, are rare forms of cancer of the lymphocyte (a type of white blood cell that fights infection in the body) that primarily manifest in the skin, but may spread to the lymph nodes, blood and other organs. All cutaneous lymphomas are non-Hodgkin lymphomas.
Most cases of cutaneous lymphoma have no known cause, and therefore, they are difficult to prevent. Understanding why the lymphocytes on the skin become cancerous in the skin is a current research focus here at City of Hope. » Continue Reading
Curing HIV, not simply controlling its replication, is the ultimate goal of HIV researchers. A new clinical trial at City of Hope could put that goal within reach.
The trial will test an innovative new therapy that modifies the stem cells of patients with HIV to make them resistant to infection with the virus. Here’s how it works:
The AIDS virus relies on a protein called CCR5 to penetrate and infect cells. For the trial, researchers will use a zinc finger nuclease, or ZFN, to modify blood stem cells from patients infected with HIV. The ZFN acts as a pair of molecular scissors that cuts the CCR5 gene out of the cells. Without the gene, there is no CCR protein – and researchers hope that when these cells are infused back into the patient, their immune system will be resistant to HIV.
“It’s erasing the gene, and once it’s erased, it never can reappear,” said John Zaia, M.D., in an interview with BuzzFeed News. Zaia is the Aaron D. Miller and Edith Miller Chair in Gene Therapy at City of Hope, chair of the Department of Virology and principal investigator of the trial. » Continue Reading
Equipping the immune system to fight cancer – a disease that thrives on mutations and circumventing the body’s natural defenses – is within reach. In fact, City of Hope researchers are testing one approach in clinical trials now.
Scientists take a number of steps to turn cancer patients’ T cells – white blood cells that are part of the immune system’s defenses – into smart cells that can locate elusive cancer cells. They also get help from nature, using the natural properties of what most people consider agents of infection.
First, they use bacteria to help the patient’s own T cells grow in the lab – because cell reproduction is something bacteria do very well. Then they use a harmless virus to manipulate the DNA of the T cell so it can recognize certain markers on a cancer cell that flag them as targets for attack.
KPCC recently reported on this research, explaining how the immune system might be mobilized to attack cancers that are good at hiding from the body.
Bacteria, viruses, a patient’s own immune system and a team of top scientists all working in concert against cancer … Sound complicated? In about two and a half minutes, the above video artfully sums up the process step by step.
So far, City of Hope is studying this approach in a number of blood cancers through the Hematologic Malignancies and Stem Cell Transplantation Institute.
Learn more about T cell immunotherapy at City of Hope.
Learn more about becoming a patient or getting a second opinion at City of Hope by visiting our website or by calling 800-826-HOPE (4673). City of Hope staff will explain what’s required for a consult at City of Hope and help you determine, before you come in, whether or not your insurance will pay for the appointment.
Aaron Bomar and his family were celebrating his daughter’s 33rd birthday in September 2014 when he received alarming news: According to an X-ray taken earlier that day at an urgent care facility, he had a node on his aorta and was in danger of an aneurysm.
Bomar held hands with his wife and daughter and said a prayer. His daughter, Jessica Bomar Karylyle, blew out her candles, wishing for her 58-year-old father’s good health, and the family headed to the emergency room.
Earlier in 2014, Bomar, of Antelope Valley, had been treated for skin cancer. Lumps had developed on his face, ears and neck, making his doctors suspect another illness was also in play, but Bomar had been reluctant to have the lumps checked out. He couldn’t afford health insurance and, as the sole provider for his family, he feared he simply couldn’t pay the medical bills.
But Bomar had grown sicker by the day, quickly losing weight, and the lumps grew to golf-ball and soft-ball size. A concrete masonry inspector, Bomar is described by his daughter as strong, unflappable – and not terribly eager to go to the doctor. Finally, his wife, Julie, had convinced him to go to urgent care on that September day; there he had received the X-ray that prompted the family to go to an emergency room in Sylmar. » Continue Reading
HIV/AIDS researchers are determined not only to cure the disease, but to develop ever-more-effective treatments until that ultimate goal is reached. In 2015, they will gain ground in both endeavors.
In search of a cure: Stem cell and gene therapy
One of the most promising prospects for curing HIV is to recreate the success of the so-called Berlin patient, a patient with HIV who received a stem cell transplant to treat his acute myeloid leukemia. The transplant cured the man’s HIV because the donor had a previously unknown mutation that prevents the body from creating a key white blood cell receptor needed to establish an HIV infection.
The challenge for scientists has been to overcome the need to find a donor with the mutation who would also be a stem cell match for the patient with HIV/AIDS – a rare combination. Now City of Hope scientists have two promising approaches – both using stem cells. The approaches will be studied in City of Hope’s new Alpha Clinic for Cell Therapy and Innovation, funded by an $8 million grant from the California Institute for Regenerative Medicine. » Continue Reading