Posts tagged ‘cancer’
How does the environment affect our health? Specifically, how does it affect our risk of cancer?
City of Hope physicians and researchers recently answered those questions in an Ask the Experts event in Corona, California, explaining the underlying facts about how the environment can affect our health.
Moderator Linda H. Malkas, Ph.D., associate chair and professor of molecular and cellular biology, led the discussion, giving voice to the concerns that many people have about the environment and cancer risk, and asking tough questions of the panelists.
Breast cancer treatment can damage a woman’s ability to become pregnant, making the impact on fertility one of the key factors that many consider when choosing a therapy regimen. Now a study has found that breast cancer patients treated with a hormone-blocking drug in addition to chemotherapy were less likely to experience ovarian failure and more likely to have successful pregnancies.
Although the study on breast cancer and fertility has some limitations, it could suggest an alternative strategy for women who hope to become pregnant after breast cancer treatment, said George Somlo, M.D., a professor of breast oncology and staff physician at City of Hope. He was not involved in the study, but provided outside expert commentary in an interview with Medpage Today.
The Cleveland Clinic study, published in the New England Journal of Medicine, found that women who received goserelin – a synthetic version of a naturally occurring hormone – during chemotherapy experienced an 8 percent ovarian failure rate, compared to 22 percent among women who did not receive the drug. In addition, 21 percent of women who received goserelin became pregnant within five years post-treatment, compared to 11 percent of women in the control group during the same time frame.
Somlo elaborated on his perspective in this Q and A. » Continue Reading
The breakthroughs that have revolutionized cancer treatment, transforming cancer in many cases to a very manageable and even curable disease, started out as just ideas.
“I will often tell patients there’s no therapy we’re using to help them that wasn’t derived from somebody’s idea in some laboratory, working late into the night,” said Stephen J. Forman, M.D., Francis & Kathleen McNamara Distinguished Chair in Hematology and Hematopoietic Cell Transplantation at City of Hope. “There’s a challenge, I think, maintaining a certain level of funding so that all good ideas get a chance to see if they’re going to help someone.”
The commitment to that ingenuity, along with the ability to seamlessly and safely bring those ideas from the laboratory to the patient, are what set City of Hope apart. The challenges in translating medicine into practical benefit, the future of precision medicine, how the field of cancer treatment has evolved and the role of 101-year-old City of Hope were the topics recently on “Charlie Rose,” a nationally syndicated show on PBS and Bloomberg television.
City of Hope President and Chief Executive Officer Robert W. Stone, Provost and Chief Scientific Officer Steven T. Rosen, M.D., and Forman sat down with Rose in an interview that aired Feb. 25. » Continue Reading
Think twice before tossing out those hormone replacement pills. Although a new Lancet study suggests that hormone replacement therapy could increase a woman’s risk of ovarian cancer, a City of Hope expert urges women to keep this news in perspective.
Hormone replacement therapy is prescribed to help alleviate symptoms, such as hot flashes and night sweats, that can damage quality of life in menopausal women. The University of Oxford study found that women who used hormone replacement therapy for less than five years after menopause had a 40 percent higher risk of ovarian cancer than other women.
However, while the statistical finding is an important one, the study was not designed to definitively show that the hormone therapy caused the increased ovarian cancer risk. No mechanism has been identified.
Robert Morgan, M.D., co-director of the gynecological cancers program at City of Hope, said that women do indeed face a slightly increased risk of ovarian cancer when using hormone replacement, but that the overall risk for the general population is very low. Over 21,000 women are expected to be diagnosed with ovarian cancer this year, according to the American Cancer Society, and over 14,000 are expected to die of the disease.
“The fact alone of a slight increased risk of ovarian cancer in women taking hormone therapy won’t, and shouldn’t, impact treatment decisions,” Morgan said in a HealthDay interview. » Continue Reading
With precision medicine now a national priority, City of Hope has joined a novel research partnership designed to further understanding of cancer at the molecular level, ultimately leading to more targeted cancer treatments.
The Oncology Research Information Exchange Network, or ORIEN, is the world’s largest precision collaboration for cancer research, one that will enable researchers and clinicians to share data to accelerate the development of precision medicine treatments. This will allow patients to be more quickly matched to potentially lifesaving clinical trials, even as it leads to larger and richer analyses of data for research purposes.
ORIEN is anchored by the Moffitt Cancer Center and the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richaed J. Solove Research Institute. City of Hope joins the network at the same time as University of Virginia Cancer Center, University of Colorado Cancer Center and University of New Mexico Cancer Center, expanding the oncology network from coast to coast. » Continue Reading
Although many Hispanic women face a high risk of mutations in the BRCA1 and BRCA2 genes – increasing their risk of breast and ovarian cancer – screenings for these mutations can be prohibitively expensive in Mexico and other Latin American countries. As a result, too many women don’t get the information they need to make informed health choices.
City of Hope researchers may have found a solution to this problem: testing for the specific mutations most common in women of Hispanic descent.
In findings reported in Cancer, the journal of the American Cancer Society, researchers reported that they were able to detect 68 percent of all BRCA mutations in a recent study’s participants by using a HISPANEL – a test panel developed by Jeffrey Weitzel, M.D., director of the Division of Clinical Cancer Genetics at City of Hope. Further, by focusing on these specific mutations, rather than the full range of all possible BRCA1 and BRCA2 mutations, the cost of testing amounted to only 2 percent of the cost of testing for all BRCA mutations. » Continue Reading
Providing lung cancer treatments to patients when their cancer is at its earliest and most treatable stages will now be a more attainable goal: Medicare has agreed to cover lung cancer screening for those beneficiaries who meet the requirements.
The only proven way to detect lung cancer early enough to save lives is through low-dose computed tomography (CT) screening. One of the largest randomized, controlled clinical trials in the National Cancer Institute’s history showed that this screening could reduce lung cancer mortality rates by at least 20 percent. This is a significant reduction; lung cancer currently has a five-year survival rate of 17 percent. For people diagnosed at advanced stages, survival rates are less than 4 percent.
“Finally, seniors who are at high risk for lung cancer can undergo screening without the barrier of out-of-pocket costs,” said Dan Raz, M.D., co-director of the Lung Cancer and Thoracic Oncology Program at City of Hope. “Medicare got this right because lung cancer screening saves lives in high-risk current and former smokers. In fact, the low-dose CT scan to screen for lung cancer has the potential to save more lives than any cancer test in history.” » Continue Reading
At City of Hope, innovative scientific research, important clinical studies and vital construction projects are all powered by philanthropy. Generous supporters fuel a powerful and diverse range of progress in science and medicine, enabling researchers and clinicians to improve cancer treatments and create cures not just for cancer, but also for diabetes and other life-threatening illnesses.
Take a look at what City of Hope supporters have helped build, launch and create over the past year:
Improving care through science
Innovative approaches: In 2014, John Williams, Ph.D., associate professor of molecular medicine, pushed ahead in his research on meditope technology. As described in the Proceedings of the National Academy of Sciences, these engineered peptides “fit” into antibodies, much like a lock and key, making it possible to selectively deliver material to cancer cells.
This research has already earned funding from the prestigious W. M. Keck Foundation, which is helping Williams’ team advance its applications. Those include the recent development of several new meditopes that can be attached to therapeutic antibodies targeting several different forms of cancer, including breast cancer. » Continue Reading
Valentine’s Day is synonymous with dinner reservations, red roses, heart-shaped boxes of chocolates and — more often than not — unrealistically high expectations.
Managing those expectations is great advice for all couples on Feb. 14 — and is especially important for couples confronting a cancer diagnosis. Focus on the opportunity to connect as a couple in a way that is most meaningful for you, and not what others think Valentine’s Day is about, advises Courtney Bitz, L.C.S.W., head of the Couples Coping with Cancer Together program, offered through the Sheri & Les Biller Patient and Family Resource Center.
“During Valentine’s Day, couples may feel pressure to do what they did prior to the cancer diagnosis or what everyone else is doing,” Bitz says. “I encourage couples to openly communicate about these external and internal expectations so they can work together on how they can best feel connected to one another.”
Couples Coping with Cancer Together provides couples therapy to couples confronting a breast cancer diagnosis as part of their standard medical care. Bitz’s advice can be applied to all couples who are dealing with cancer. The support of a spouse or partner is especially important during cancer care, but keeping a close and intimate connection can be challenging when one or both members of a couple are feeling emotionally and physically taxed.
Bitz offers this Valentine’s Day advice: » Continue Reading
With measles, what starts at a theme park in California definitely doesn’t stay at a theme park in California. Since the beginning of the current measles outbreak – traced to an initial exposure at Disneyland or Disney California Adventure during December – more than 100 people have been diagnosed with a disease wrongly considered to have been vanquished.
The all-but-forgotten hallmark of childhood is now rippling across the country – with people from New York to Washington, Arizona to Georgia, affected. Beyond fever, cough, red eyes, runny nose and the signature red rash, the disease can lead to ear infections, diarrhea and, in more severe cases, pneumonia, encephalitis and death. One or two of every 1,000 children who develop the disease die from it.
To say the disease is highly contagious would be an understatement. Every new diagnosis makes clear what can happen in a population largely unexposed to measles, with a spotty vaccination record against it. But much remains unknown, including how worried cancer patients should be.
Bernard Tegtmeier, Ph.D., a clinical microbiologist and an expert in the spread of infectious diseases, offered some perspective in this interview. » Continue Reading