Posts tagged ‘cancer’


Charlie Rose: Experts talk of cancer breakthroughs and ‘tyranny of time’

February 26, 2015 | by
Charlie Rose

Charlie Rose interviews, from left, City of Hope’s Stephen J. Forman, Steven T. Rosen and City of Hope President and CEO Robert W. Stone.

The breakthroughs that have revolutionized cancer treatment, transforming cancer in many cases to a very manageable and even curable disease, started out as just ideas.

“I will often tell patients there’s no therapy we’re using to help them that wasn’t derived from somebody’s idea in some laboratory, working late into the night,” said Stephen J. Forman, M.D., Francis & Kathleen McNamara Distinguished Chair in Hematology and Hematopoietic Cell Transplantation at City of Hope. “There’s a challenge, I think, maintaining a certain level of funding so that all good ideas get a chance to see if they’re going to help someone.”

The commitment to that ingenuity, along with the ability to seamlessly and safely bring those ideas from the laboratory to the patient, are what set City of Hope apart. The challenges in translating medicine into practical benefit, the future of precision medicine, how the field of cancer treatment has evolved and the role of 101-year-old City of Hope were the topics recently on “Charlie Rose,” a nationally syndicated show on PBS and Bloomberg television.

City of Hope President and Chief Executive Officer Robert W. Stone, Provost and Chief Scientific Officer Steven T. Rosen, M.D., and Forman sat down with Rose in an interview that aired Feb. 25. » Continue Reading


Take measured view of study on ovarian cancer risk, expert advises

February 25, 2015 | by

Think twice before tossing out those hormone replacement pills. Although a new Lancet study suggests that hormone replacement therapy could increase a woman’s risk of ovarian cancer, a City of Hope expert urges women to keep this news in perspective.

hormone pills

Don’t lose perspective when weighing the recent study linking hormone replacement therapy to a higher risk of ovarian cancer, one expert advises.

Hormone replacement therapy is prescribed to help alleviate symptoms, such as hot flashes and night sweats, that can damage quality of life in menopausal women. The University of Oxford study found that women who used hormone replacement therapy for less than five years after menopause had a 40 percent higher risk of ovarian cancer than other women.

However, while the statistical finding is an important one, the study was not designed to definitively show that the hormone therapy caused the increased ovarian cancer risk. No mechanism has been identified.

Robert Morgan, M.D., co-director of the gynecological cancers program at City of Hope, said that women do indeed face a slightly increased risk of ovarian cancer when using hormone replacement, but that the overall risk for the general population is very low. Over 21,000 women are expected to be diagnosed with ovarian cancer this year, according to the American Cancer Society, and over 14,000 are expected to die of the disease.

“The fact alone of a slight increased risk of ovarian cancer in women taking hormone therapy won’t, and shouldn’t, impact treatment decisions,” Morgan said in a HealthDay interview. » Continue Reading


ORIEN network will accelerate data exchange – and new cancer therapies

February 23, 2015 | by

With precision medicine now a national priority, City of Hope has joined a novel research partnership designed to further understanding of cancer at the molecular level, ultimately leading to more targeted cancer treatments.

precision medicine

City of Hope has joined ORIEN, the world’s largest cancer research collaboration devoted to precision medicine.

The Oncology Research Information Exchange Network, or ORIEN, is the world’s largest precision collaboration for cancer research, one that will enable researchers and clinicians to share data to accelerate the development of precision medicine treatments. This will allow patients to be more quickly matched to potentially lifesaving clinical trials, even as it leads to larger and richer analyses of data for research purposes.

ORIEN is anchored by the Moffitt Cancer Center and the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richaed J. Solove Research Institute. City of Hope joins the network at the same time as University of Virginia Cancer Center, University of Colorado Cancer Center and University of New Mexico Cancer Center, expanding the oncology network from coast to coast. » Continue Reading


New screening panel could target BRCA mutations common to Hispanic women

February 19, 2015 | by

Although many Hispanic women face a high risk of mutations in the BRCA1 and BRCA2 genes – increasing their risk of breast and ovarian cancer – screenings for these mutations can be prohibitively expensive in Mexico and other Latin American countries. As a result, too many women don’t get the information they need to make informed health choices.

BRCA gene mutations in Hispanic women

Many Hispanic women carry specific mutations in the BRCA genes. Now City of Hope researchers have developed a panel that could  spot  these BRCA mutations, helping them make more informed decisions.

City of Hope researchers may have found a solution to this problem: testing for the specific mutations most common in women of Hispanic descent.

In findings reported in Cancer, the journal of the American Cancer Society, researchers reported that they were able to detect 68 percent of all BRCA mutations in a recent study’s participants by using a HISPANEL – a test panel developed by Jeffrey Weitzel, M.D., director of the Division of Clinical Cancer Genetics at City of Hope. Further, by focusing on these specific mutations, rather than the full range of all possible BRCA1 and BRCA2 mutations, the cost of testing amounted to only 2 percent of the cost of testing for all BRCA mutations. » Continue Reading


Need lung cancer screening? Medicare will pay for some beneficiaries

February 18, 2015 | by

Providing lung cancer treatments to patients when their cancer is at its earliest and most treatable stages will now be a more attainable goal: Medicare has agreed to cover lung cancer screening for those beneficiaries who meet the requirements.

lung cancer screening

Medicare will now cover annual lung cancer screening for seniors who qualify using low-dose CT scans.

The only proven way to detect lung cancer early enough to save lives is through low-dose computed tomography (CT) screening. One of the largest randomized, controlled clinical trials in the National Cancer Institute’s history showed that this screening could reduce lung cancer mortality rates by at least 20 percent. This is a significant reduction; lung cancer currently has a five-year survival rate of 17 percent. For people diagnosed at advanced stages, survival rates are less than 4 percent.

“Finally, seniors who are at high risk for lung cancer can undergo screening without the barrier of out-of-pocket costs,” said Dan Raz, M.D., co-director of the Lung Cancer  and Thoracic Oncology Program at City of Hope. “Medicare got this right because lung cancer screening saves lives in high-risk current and former smokers. In fact, the low-dose CT scan to screen for lung cancer has the potential to save more lives than any cancer test in history.” » Continue Reading


Powered by philanthropy: Bold science, better cancer treatments

February 17, 2015 | by
Impact of cancer research

At City of Hope, the breakthroughs discovered here are shared with cancer researchers, clinicians and patients worldwide.

At City of Hope, innovative scientific research, important clinical studies and vital construction projects are all powered by philanthropy. Generous supporters fuel a powerful and diverse range of progress in science and medicine, enabling researchers and clinicians to improve cancer treatments and create cures not just for cancer, but also for diabetes and other life-threatening illnesses.

Take a look at what City of Hope supporters have helped build, launch and create over the past year:

Improving care through science

Innovative approaches: In 2014, John Williams, Ph.D., associate professor of molecular medicine, pushed ahead in his research on meditope technology. As described in the Proceedings of the National Academy of Sciences, these engineered peptides “fit” into antibodies, much like a lock and key, making it possible to selectively deliver material to cancer cells.

This research has already earned funding from the prestigious W. M. Keck Foundation, which is helping Williams’ team advance its applications. Those include the recent development of several new meditopes that can be attached to therapeutic antibodies targeting several different forms of cancer, including breast cancer. » Continue Reading


Valentine’s Day advice for couples facing cancer: Ignore expectations

February 13, 2015 | by

Valentine’s Day is synonymous with dinner reservations, red roses, heart-shaped boxes of chocolates and — more often than not — unrealistically high expectations.

Valentine's Day

On Valentine’s Day, couples coping with cancer should drop the expectations that come with the holiday, and focus on what’s important to them as a couple.

Managing those expectations is great advice for all couples on Feb. 14 — and is especially important for couples confronting a cancer diagnosis. Focus on the opportunity to connect as a couple in a way that is most meaningful for you, and not what others think Valentine’s Day is about, advises Courtney Bitz, L.C.S.W., head of the Couples Coping with Cancer Together program, offered through the Sheri & Les Biller Patient and Family Resource Center.

“During Valentine’s Day, couples may feel pressure to do what they did prior to the cancer diagnosis or what everyone else is doing,” Bitz says. “I encourage couples to openly communicate about these external and internal expectations so they can work together on how they can best feel connected to one another.”

Couples Coping with Cancer Together provides couples therapy to couples confronting a breast cancer diagnosis as part of their standard medical care. Bitz’s advice can be applied to all couples who are dealing with cancer. The support of a spouse or partner is especially important during cancer care, but keeping a close and intimate connection can be challenging when one or both members of a couple are feeling emotionally and physically taxed.

Bitz offers this Valentine’s Day advice: » Continue Reading


Measles and cancer: What you should know

February 13, 2015 | by

With measles, what starts at a theme park in California definitely doesn’t stay at a theme park in California. Since the beginning of the current measles outbreak – traced to an initial exposure at Disneyland or Disney California Adventure during December – more than 100 people have been diagnosed with a disease wrongly considered to have been vanquished.

Measles and cancer

Cancer patients can’t be vaccinated against the measles virus (depicted in illustration). They must rely on members of their community to keep them safe.

The all-but-forgotten hallmark of childhood is now rippling across the country – with people from New York to Washington, Arizona to Georgia, affected. Beyond fever, cough, red eyes, runny nose and the signature red rash, the disease can lead to ear infections, diarrhea and, in more severe cases, pneumonia, encephalitis and death. One or two of every 1,000 children who develop the disease die from it.

To say the disease is highly contagious would be an understatement. Every new diagnosis makes clear what can happen in a population largely unexposed to measles, with a spotty vaccination record against it. But much remains unknown, including how worried cancer patients should be.

Bernard Tegtmeier, Ph.D., a clinical microbiologist and an expert in the spread of infectious diseases, offered some perspective in this interview. » Continue Reading


Couples cope best with breast cancer when they cope together

February 12, 2015 | by

Even the most loving and secure relationship can be rattled by a life-threatening illness.

breast cancer

Couples Coping with Cancer Together integrates couples counseling as a standard part of breast cancer treatment.

When a woman is diagnosed with breast cancer, research shows one of the most important factors in helping her cope is having a supportive partner. But that partner can struggle with knowing what to say or how to best support their loved one.

Through research and clinical experience with breast cancer and relationships, City of Hope has found that specific skills and behaviors can help a couple grow closer despite the stress of cancer. That’s why City of Hope created the Couples Coping with Cancer Together program, which is solely funded by private donations.

“We are the only program of our kind,” said Courtney Bitz, L.C.S.W., a social worker in the Sheri & Les Biller Patient and Family Resource Center and head of the Couples Coping with Cancer Together program. “We make this support and counseling a standard part of the care. We normalize it, and take away the stigma. Even the healthiest of couples can struggle – it’s not only couples who were already having difficulties who struggle with a cancer diagnosis.” » Continue Reading


Observe World Cancer Day by reducing your cancer risk. Here’s how:

February 2, 2015 | by

With this week’s World Cancer Day challenging us to think about cancer on a global scale, we should also keep in mind that daily choices affect cancer risk on an individual scale. Simply put, lifestyle changes and everyday actions can reduce your cancer risk and perhaps prevent some cancers.

cancer risk reduction

Choosing healthy foods, exercise and other healthy habits are essential to cancer risk reduction.

According to the World Cancer Research Fund, about a third of the most common cancers could be prevented through reduced alcohol consumption, healthier diets and improved physical activity levels. If smoking were also eliminated, that number could jump to as many as half of all common cancers.

Here are a few suggestions. Truly, they’re not that difficult. Give them a try this week to mark World Cancer Day, Feb. 4, Try them the next week too. And the week after that …

In a word, exercise. Simple exercise benefits everyone, and even a little helps. Leslie Bernstein, Ph.D., professor and director of the Division of Cancer Etiology at City of Hope, recommends a 45-minute walk five days a week. While that is ideal, her research has found that, for some people, even 30 minutes per week can make a difference. The benefit of exercise applies for people of all weights and fitness levels.

The American Cancer Society recommends 150 minutes of moderate intensity or 75 minutes of high intensity exercise each week, preferably spread throughout the week. Don’t deny yourself the benefits just because you don’t have a large block of time or can’t get into the gym for a more formal workout. » Continue Reading