Posts tagged ‘breast cancer research’

Veliparib shows promise for BRCA-related breast cancer patients

January 10, 2014 | by
Of the estimated 230,000 new cases of breast cancer diagnosed annually in the U.S., approximately 12,000 patients carry harmful mutations on either the BRCA1 or BRCA2 genes. Researchers are investigating the effectiveness of various drugs against breast cancer, including the PARP inhibitor veliparib. Cancer cells carrying these mutations are unable to properly repair double-strand DNA. Because specific enzymes – poly ADP-ribose polymerase 1 and 2 (known as PARP1 and PARP2) – are needed for DNA repair in malignant (as well as normal) cells, drugs known as PARP inhibitors often are used to help kill the cells. As George Somlo, M.D.,  professor in City…