Posts tagged ‘breast cancer research’

With breast cancer treatment, expertise – and research – matter

October 23, 2014 | by

The breast cancer statistic is attention-getting: One in eight women will be diagnosed with breast cancer during her lifetime. That doesn’t mean that, if you’re one of eight women at a dinner table, one of you is fated to have breast cancer (read more on that breast cancer statistic), but it does mean that the risk of developing breast cancer is not to be taken lightly. Neither is the decision on where to get breast cancer treatment.

Breast cancer treatment and research

In breast cancer treatment, location matters. That location should also be the home of research. City of Hope understands this.

As a nationally known biomedical research institution and as one of the nation’s few comprehensive cancer centers, City of Hope can provide access to therapies, research and clinical trials that other hospitals can’t.

Let’s start with clinical trials and research. The clinical trials available to City of Hope patients often stem from the research conducted on the City of Hope campus, where breast cancer specialists and researchers work together on therapies to improve survival and quality of life. Those clinical trials include assessments of new chemotherapy drugs, targeted therapies, hormone therapies, new surgical techniques and new radiation approaches — all focused on improving breast cancer treatment, detection and prevention. » Continue Reading

Breast cancer awareness has been raised. Now it’s time for action

October 1, 2014 | by

This time of year, how can anyone not think pink? Through the power of pastel packaging, October has been etched permanently into the American public’s consciousness as Breast Cancer Awareness Month. The color pink is now synonymous with breast cancer.

breast cancer awareness

If you recognize this symbol as a Breast Cancer Awareness Month ribbon, you’re awareness of breast cancer has been raised. Now it’s time to take action.

Suffice to say, awareness has been raised.

Now it’s time to make the most of that awareness. Now it’s time for action. That action can come when you choose a health plan, when you choose an oncologist, when you donate or even when you shop for a purse, a tape dispenser or a really great moisturizer.

* If you’re choosing a health plan, choose one that provides access to top-of-the-line expertise.

Research by Julie Wolfson, M.D., M.S.H.S., assistant professor of City of Hope’s Department of Pediatrics and Department of Population Sciences, has found that, in cancer, where you get care matters. » Continue Reading

Radiation linked to lower lymphedema risk in breast cancer patients

April 30, 2014 | by

For some breast cancer patients whose cancer has also spread to their axillary lymph nodes, radiation might be a better option than surgically removing the nodes, a new study suggests.

A new study finds radiation poses a lower risk of lymphedema for women treated for breast cancer that has spread to the lymph nodes than removing the nodes.

A new study finds radiation poses a lower risk of lymphedema for women treated for breast cancer that has spread to the lymph nodes than removing the nodes.

Previous studies have shown that, when looking strictly at survival, both approaches are about equal. The new study finds that radiation therapy, which is emerging as a treatment protocol for breast cancer affecting the lymph nodes, is associated with significantly fewer complications than removal of the nodes.

The results from the international multicenter trial are being presented in Las Vegas at Breast Cancer Update 2014, the 15th annual meeting of the American Society of Breast Surgeons. The study included nearly 5,000 randomized patients. It found those patients with positive sentinel nodes treated with radiation suffered less lymphedema – swelling, usually in the arms or legs associated with blockage in the lymphatic system – as well as less arm parasthesia and other postsurgery complications.

But breast cancer specialists aren’t advising women to automatically choose radiation over lymph node removal. » Continue Reading

Veliparib shows promise for BRCA-related breast cancer patients

January 10, 2014 | by

Of the estimated 230,000 new cases of breast cancer diagnosed annually in the U.S., approximately 12,000 patients carry harmful mutations on either the BRCA1 or BRCA2 genes.

breast cancer

Researchers are investigating the effectiveness of various drugs against breast cancer, including the PARP inhibitor veliparib.

Cancer cells carrying these mutations are unable to properly repair double-strand DNA. Because specific enzymes – poly ADP-ribose polymerase 1 and 2 (known as PARP1 and PARP2) – are needed for DNA repair in malignant (as well as normal) cells, drugs known as PARP inhibitors often are used to help kill the cells.

As George Somlo, M.D.,  professor in City of Hope’s Department of Medical Oncology & Therapeutics Research, puts it: In BRCA1- or BRCA2-related  breast cancer, exposing the cancer cells to PARP inhibitors greatly enhances the potential for  irreversible single- or double-strand DNA damage.

In the fight against cancer, that kind of DNA damage is ideal.

Now Somlo and his colleagues are learning even more about how a specific PARP inhibitor, called veliparib (or ABT-888), could improve cancer treatment. » Continue Reading