Posts tagged ‘bladder cancer’


Bladder cancer patient has a mission: Cure metastatic bladder cancer

March 27, 2015 | by
Frank Di Bella, pictured with Sumanta Kumar Pal, M.D., raised more than $1.6 million for metastatic bladder cancer research led by Pal at City of Hope.

Frank Di Bella (right), pictured with Sumanta Kumar Pal, has already helped raise more than $1.6 million for metastatic bladder cancer research led by Pal at City of Hope.

Frank Di Bella, 70, is on a mission: Find a cure for metastatic bladder cancer.

It’s just possible he might.

Although Di Bella isn’t a world-renowned physician, cancer researcher or scientist, he knows how to make things happen. For more than 20 years, he served as chairman of annual fundraising galas on behalf of muscular dystrophy research, and he’s successfully raised more than $10 million toward that cause.

Now his attention is focused on his own disease: metastatic bladder cancer. The former business consultant recently held a black-tie gala titled “Let’s Be Frank about Cancer” to help raise funds for City of Hope’s bladder cancer research, led by Sumanta Kumar Pal, M.D.

The gala was filled with distinguished leaders, such as Gov. Jerry Brown, and brought in more than $1.6 million for Pal’s research.

But for Di Bella, that’s just the start.

“I’m going to spend the rest of my life raising money to help City of Hope and Dr. Pal,” Di Bella said.

» Continue Reading


Cancer Insights: The dawn of precision medicine for cancer

March 17, 2015 | by

“Tonight, I’m launching a new precision medicine initiative to bring us closer to curing diseases like cancer.” These were the words of President Barack Obama on Jan. 20, 2015, during his State of the Union address. So what is precision medicine, and how close are we to making it a reality for patients?

Potential of precision medicine

Precision medicine is rapidly becoming a reality. With it comes an unprecedented potential to treat patients as the individuals they are.

Let’s begin with some definitions. Precision medicine entails two general tenets: (1) understanding the biology of an individual patient’s cancer, and (2) treating the patient according to this biology. When I was in medical school, both elements would have been perceived as a pipe dream. Now, they are slowly becoming a reality.

Comprehensive genetic tests that used to take days to weeks to run can now be done in minutes; these tests can point an oncologist toward specific medications that target proteins at the cancer cell surface, while sparing normal cells. In contrast to chemotherapy (which attacks cells indiscriminately), targeted therapies may potentially have fewer side effects. » Continue Reading


Meet our doctors: Surgeon Donald Hannoun on urology and bladder cancer

February 7, 2015 | by

The treatment of urologic cancers, including bladder cancer, is rapidly evolving. Here, urologic oncologic surgeon and kidney stone specialist Donald Hannoun, M.D., an assistant clinical professor in the Division of Urology and Urologic Oncology at City of Hope | Antelope Valley, explains the changes in his field, as well as his approach to medicine.

Urologist Donald Hannoun

Donald Hannoun shares his approach to urology and patient care.

Did someone or something from your early experience in life motivate you to go into medicine?

I’ve always loved working with people.  I couldn’t think of a more altruistic field than medicine. What motivated me to get into urology was my late grandfather’s struggle with bladder stones, which are hard masses of minerals in the bladder. He was completely miserable before his surgery, and was then transformed into a new man after having them removed. To see such immediate results made me seriously consider urology. Now, I treat all types of genitourinary cancers, including kidney, bladder, prostate and testicular cancer.

» Continue Reading


Cancer research 2015: T cell immunotherapy, targeted drugs and more

January 1, 2015 | by

Every year, researchers make gains in the understanding of cancer, and physicians make gains in the treatment of cancer. As a result, every year, more cancer patients survive their disease.

2015 in cancer research

In 2015, cancer research will move forward in ways both high-profile and little-heralded.

In those ways, 2015 will be no different. What will be different are the specific research discoveries and the specific advances in screening and treatment. We asked City of Hope experts to weigh in on the research and treatment advances they predict for the year to come.

Some of those advances will make headlines around the world – expect to hear much more about T cell therapy and targeted drug therapy – while some will garner attention largely among those affected by, or treating, the disease.

But all will have an impact. » Continue Reading


Bladder cancer 2015: Personalized medicine meets ‘molecular selection’

December 28, 2014 | by

Surgery for bladder cancer isn’t what it used to be; it’s better – much better. Advances in robotic surgeries have greatly improved both the options and the quality of life for people diagnosed with bladder cancer.

bladder cancer

City of Hope is leading several innovative studies in bladder cancer, with two of them focusing on what’s known as a molecular selection process.

These advances, which are constantly giving way to even newer ones, mean that the entire bladder doesn’t always have to be removed. When it does, not only can highly skilled surgeons sometimes create an artificial bladder, they can even create an internal reservoir (different from a bladder and known as an Indiana pouch) using the large intestine and part of the small intestine. Such alternatives are usually preferred  over the need for an external bag to collect the urine.

Much work remains, however, in the understanding of bladder cancer. Sumanta Pal, M.D., co-director of the Kidney Cancer Program at City of Hope, is leading several innovative studies in bladder cancer, with two of them focusing on what’s known as a molecular selection process. » Continue Reading


Bladder cancer patient and fitness instructor can still wear a bikini (w/VIDEO)

August 19, 2014 | by

Christine Crews isn’t only a fitness enthusiast, she’s also a personal trainer and fitness instructor. Being active defines her life. So when she was diagnosed with bladder cancer at age 30, she decided she absolutely couldn’t let the disease interfere with that lifestyle.

And it didn’t. For the next 15 years, Crews continued to run marathons, teach fitness classes and train 20 to 30 clients a week, all while fighting her bladder cancer with chemotherapy and periodic tumor removals.

By the age of 45, however, the cancer had spread to 80 percent of her bladder. She was told she would need a cystectomy, that is, the surgical removal of her bladder. » Continue Reading


With cancer, expertise matters – as these cancer patients know (w/VIDEO)

August 12, 2014 | by

A patient diagnosed with cancer – especially a rare, advanced or hard-to-treat cancer – needs specialized care from exceptionally skilled and highly trained experts. That kind of care saves lives, improves quality of life and keeps families whole.

That kind of care is best found at comprehensive cancer centers like City of Hope.

One of the top cancer hospitals for cancer in the United States, according to U.S.News & World Report’s annual rankings, City of Hope has also been awarded the highest level of accreditation from the American College of Surgeons Commission on Cancer and is listed on Becker’s Hospital Review’s 2014 list of “100 Hospitals and Health Systems With Great Oncology Programs.”

Further, recent research found that receiving cancer care at a comprehensive cancer center improves survival of patients with cancers of the breast, lung, liver, stomach, pancreas and oral tissues, among others.

The cancer patients in the video above don’t need to be convinced by such commendations or research, however. They were convinced by City of Hope itself.

Read more about them:

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Learn more about becoming a patient or getting a second opinion at City of Hope by visiting us online or by calling 800-826-HOPE (4673). City of Hope staff will explain what’s required for a consult at City of Hope and help you determine, before you come in, whether or not your insurance will pay for the appointment.


Bladder cancer patient finds he has an alternative to external device

July 9, 2014 | by

When Sheldon Querido, a retired manufacturer’s representative, was diagnosed with bladder cancer, his doctor told him that he’d need to have his bladder removed – and that he’d have to wear an external urine-collection bag for the rest of his life.

Neobladder

An artificial bladder, called a neobladder, enables patients to urinate normally, eliminating the need for an external bag and allowing patients to transition back to their normal life after surgery.

“My first response was ‘I don’t want to live like that,” Querido told ABC 7 in a recent interview. “That’s gonna be a terrible way to live.”

Querido simply couldn’t accept that collecting his urine externally was his only option. The Thousand Oaks resident and his wife decided to get a second opinion at City of Hope. There, they learned there was indeed another choice: an artificial bladder, called a neobladder, built by specialists at City of Hope. » Continue Reading


Urologic cancers: Dispatches from research’s front lines

March 28, 2014 | by

Urologic cancers, including prostate cancer, kidney cancer and bladder cancer, are diagnosed in more than 381,000 Americans each year, and almost 60,000 people die from the diseases. City of Hope’s physicians and scientists are determined to reduce those numbers.

Our groundbreaking research holds the promise of better treatments and cures for the millions of people worldwide battling these difficult cancers. The Division of Urology and Urologic Oncology, led by Timothy Wilson, M.D., Pauline & Martin Collins Family Chair in Urology and director of the Prostate Cancer Program, report the following developments in the treatment of urologic cancers.

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Overcoming drug resistance in metastatic prostate cancer

African American men are 60 percent more likely than white men to get prostate cancer and 2.4 times more likely to die of the disease.

The drug pyrvinium shows promise in the treatment of prostate cancer. Even better, it doesn’t target testosterone.

When prostate cancer metastasizes, it is signaled to grow by a protein called the androgen receptor, which is activated by testosterone. Many men initially respond to hormone treatments that inhibit testosterone, but prostate cancer cells adapt and develop resistance to these therapies, and the cancer almost always returns.

Jeremy Jones, Ph.D., assistant professor of Molecular Pharmacology, found that pyrvinium, a drug used for decades to treat pinworm infections, could treat metastatic prostate cancer without targeting testosterone. Pyrvinium works by inhibiting the DNA binding domain – a different part of the androgen receptor that’s activated when testosterone is blocked –  and could be effective when all other therapies have failed. Jones is testing pyrvinium derivatives in cell cultures and mice, and his goal is to reach phase I clinical trial in the next two years.

Jones is also working with Cy Stein, M.D., Ph.D., Arthur & Rosalie Kaplan Chair of Medical Oncology, to combine the action of two drugs, enzalutamide and abiraterone, to treat prostate cancer that is resistant to hormone therapy. They have designed a compound called COH11023 that inhibits the production of testosterone, prevents testosterone from binding to the androgen receptor and breaks down the androgen receptor to rid the cancer cells of the protein. » Continue Reading


Bladder cancer patient fought symptoms for 15 years (w/VIDEO)

March 13, 2014 | by

Christine Crews thought she had a bladder infection. Turns out, the Memphis, Tenn., resident had bladder cancer. For 15 years, she fought it with chemotherapy and occasional tumor removals.

When the cancer spread to 80% of her bladder, she was told she would need to have her entire bladder removed. She got a second opinion. And another. Crews wasn’t comfortable with any of the recommendations; she wanted other options. When a urologist friend recommended she call City of Hope, she did.

“They actually listened to what I wanted from the surgery,” Crews said. “They were able to give me options that other hospitals were not able to give me.”

In the video above, Crews shares her story to help other people with bladder cancer understand just how special City of Hope is, and what their options really are.

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Support bladder cancer research at City of Hope and your gift will be matched dollar-for-dollar, up to $100,000, by our friends at the Post-it® Brand from 3M. Donate now.

Learn more about City of Hope’s bladder cancer program.

Read the Breakthroughs post “8 questions and answers about bladder cancer.”