LATEST POSTS

AACR report: Now is the time to invest in cancer research

September 16, 2014 | by   

Advances in cancer treatment, built on discoveries made in the laboratory then brought to the bedside, have phenomenally changed the reality of living with a cancer diagnosis. More than any other time in history, people diagnosed with cancer are more likely to survive and to enjoy a high quality of life.

Scientist in laboratory

With new drugs approved and new scientific breakthroughs, the chances of surviving cancer have never been higher. Now is the time to keep investing in cancer research.

However, much work remains to be done. On average, one American will die of cancer every minute of every day this year, according to the American Association for Cancer Research, which today released its annual Cancer Progress Report.  Following a year that saw six new cancer drugs approved, an estimated 14.5 million cancer survivors living in the United States, and considerable research breakthroughs, now is the time to continue fueling lifesaving cancer research through investment in the National Institutes of Health, National Cancer Institute and other organizations and agencies devoted to cancer research.

While gains in cancer research have been impressive, the pace of progress has been slowed due to years of budget cuts at the NIH and NCI.

“Incredible strides have been made in advancing our understanding, enhancing prevention and improving therapy of cancer,” said Steven Rosen, M.D., provost and chief scientific officer at City of Hope and director of the Comprehensive Cancer Center. “To maintain momentum with the ultimate goal of maximizing cure of these devastating diseases, the necessary funds must be available.”

» Continue Reading

Choosing health insurance? A physician shares these 5 tips

September 15, 2014 | by   

While health care reform has led to an increase in the number of people signing up for health insurance, many people remain uninsured or are not taking full advantage of the health benefits they now have. Still others are finding that, although their premiums are affordable, they aren’t able to see the doctors they want.

Health insurance form

Joseph Alvarnas says insurance should do more than fit a price point. Access to doctors and best care matter, especially for cancer patients.

Just because health care is more accessible than before, doesn’t necessarily mean it’s less confusing, says Joseph Alvarnas, M.D., director of Medical Quality and Quality, Risk and Regulatory Management at City of Hope.

“You have to realize we’re in un-navigated waters,” Alvarnas said. “We’re here to serve not only as health care providers, but educators. We need to empower people to be active participants in their care.”

» Continue Reading

More children are being diagnosed with kidney cancer and thyroid cancer

September 12, 2014 | by   

Kidney cancer rates and thyroid cancer rates in adults have continued to rise year after year. Now a new study has found that incidence rates for these cancers are also increasing in children — particularly in African-American children.

thyroid cancer in children

The rates of kidney cancer and thyroid cancer are increasing in children and adolescents, according to a new study published in the October issue of Pediatrics.

The study, published online this month in Pediatrics, examined childhood cancer incidence rates from 2001 to 2009 and found an annual increase of nearly 5 percent for thyroid cancer and a 5.4 increase for renal carcinoma, the most common type of kidney cancer.

Researchers also found that there was a 1.3 percent increase in the overall cancer trend among African-American children and adolescents.

Raynald Samoa, M.D., assistant professor in the Department of Clinical Diabetes, Endocrinology & Metabolism at City of Hope, told CBS News that the rise in pediatric patients with thyroid cancer is undeniable. “We’ve seen a dramatic increase,” said Samoa. “I think we’ve seen almost a [doubling] of referrals over past several years.”

» Continue Reading

5 things you should know about thyroid cancer

September 11, 2014 | by   

Thyroid cancer has become one of the fastest-growing cancers in the United States for both men and women. The chance of being diagnosed with the cancer has nearly doubled since 1990.

Patient's thyroid being scanned.

An increased use of diagnostic imaging tools such as ultrasounds and CT scans has led to improved detection of thyroid cancer, making it one of the fastest growing cancers in the United States.

This year an estimated 63,000 people will be diagnosed with thyroid cancer in the United States and nearly 1,900 people will die from it. These numbers may sound alarming, but thyroid cancer is still relatively rare compared to other cancers. Even better, it’s highly treatable at all stages.

Here, Robert Kang, M.D., assistant clinical professor in City of Hope’s Division of Otolaryngology/Head and Neck Surgery, presents a fuller picture of thyroid cancer and explains what you should know about the disease.

1. Thyroid cancer is one of the most treatable cancers. 

“Thyroid cancer is treatable at all stages,” said Kang. “Five-year survival outcomes for well-differentiated thyroid cancers approach 100 percent for both Stages 1 and 2. Stage 3 papillary thyroid cancers have demonstrated a five-year survival rate of 93 percent.”

Medullary thyroid cancer has a worse prognosis, and anaplastic thyroid cancer is rare, but is considered Stage 4, reflecting the poor prognosis associated with it.”

» Continue Reading

Teens, young adults with brain cancer need comprehensive cancer centers

September 10, 2014 | by   

Older teenagers and young adults traditionally face worse outcomes than younger children when diagnosed with brain cancer and other central nervous system tumors. A first-of-its-kind study shows why.

Teens with brain cancer have better outcomes at NCI-designated cancer centers.

Older adolescents and young adults with brain and spinal cord tumors have better outcomes when treated at National Cancer Institute-designated comprehensive cancer centers, research finds.

A team of researchers from the departments of Population Sciences and Pathology at City of Hope recently examined the cancer registry, looking at the entire Los Angeles County population of older adolescents and young adults — collectively known as AYAs — and children diagnosed with central nervous system (CNS) cancers, which include tumors of the brain and spinal cord.

The study included nearly 1,350 patients: children 14 years old and under and AYAs, who fall between the ages of 15 and 39. The National Cancer Institute (NCI) has determined that AYA patients form a special group because of unique challenges they face in cancer treatment, and this study was the first to assess the impact on survival of where an AYA patient receives care.

The scientists, led by Julie Wolfson, M.D., M.S.H.S., assistant professor, and Smita Bhatia, M.D., M.P.H., the Ruth Ziegler Chair in Population Sciences, found that both children and AYAs with a select group of CNS tumors who were treated at NCI-designated comprehensive cancer centers such as City of Hope fared better than those seeking care at adult community facilities. In some cases, the difference in five-year survival rates was more than 10 percent. Of special note, the AYAs with these cancers fared worse than the children, but by receiving care at an NCI-designated comprehensive cancer center, this difference was wiped away.

» Continue Reading

Diet during cancer treatment: Tips to ease dry mouth

September 8, 2014 | by   

Cancer treatment can take a toll on the mouth, even if a patient’s cancer has nothing to do with the head or throat, leading to a dry mouth, or a very sore mouth, and making it difficult to swallow or eat.

Here’s some advice from the National Cancer Institute (NCI)  on how to ease cancer-related discomfort of the mouth.

cancer treatment side effects

Popsicles can help cancer patients ease the dry mouth caused by some cancer treatments.

Dry mouth

Chemotherapy and radiation to the upper body can damage the salivary glands, reducing the production of saliva and making it harder to talk, chew and swallow food. Some medications can also be cause dry mouth. Try these tips to alleviate dry mouth: » Continue Reading

Meet our doctors: Jeffrey Wong on the future of radiation therapy

September 6, 2014 | by   

Radiation oncology is one of the three main specialties involved in the successful treatment of cancer, along with surgical oncology and medical oncology. Experts in this field, known as radiation oncologists, advise patients as to whether radiation therapy will be useful for their cancer – and how it can best be safely and effectively delivered.

Jeffrey Wong

Radiation is one of the three main treatments for cancer, with surgery and medication being the other two. Here, Jeffrey Wong explains the advances in radiation oncology and the importance of this type of treatment.

Here, Jeffrey Y.C. Wong, M.D., chair of radiation oncology at City of Hope, shares what he sees as the future of radiation oncology and the importance of this type of therapy in the treatment of cancer.

How and why did you decide to become a radiation oncologist?

I’ve always had an interest in the math, physics and engineering fields. I almost became an engineer, but decided to switch to oncology with a focus in medicine, and radiation oncology is a good blend of both. Radiation oncology is a blend of engineering, computer sciences, physics, biology and medicine, with the primary goal of helping people.

What inspires you daily to do the work you do?

I, along with my colleagues at City of Hope, have the opportunity to make a difference in patients” lives every day. For many patients, our therapies can help result in a cure of their cancer. We also have the opportunity to make a contribution to cancer research and advance the field of oncology. » Continue Reading

7 tips for managing cancer pain: First, control it early

September 4, 2014 | by   

There’s more to cancer care than simply helping patients survive. There’s more to cancer treatment than simple survival.

pain illustration

Cancer patients should report their pain to their caregivers, and enlist their doctors to help them manage it. Pain does not have to be part of daily life, even during cancer treatment, says City of Hope’s Betty Ferrell and other experts in palliative care.

Constant pain should not be part of conquering cancer,  insists Betty Ferrell, Ph.D., R.N., director of nursing research and education at City of Hope. She wants patients and caregivers alike to understand, and act on, this principle.

Ferrell, an international expert in palliative care, and her colleagues have spent years investigating pain management and the barriers that prevent patients from receiving the help and medication needed to manage their pain. Overcoming these barriers starts with understanding that pain management is vital. Even when people are fighting cancer, their day-to-day lives should not hampered by physical pain.

“Patients and caregivers need to understand that pain is important,” she said. “Pain has a tremendous impact on quality of life. There is an urgency. If pain is not controlled, their lives are out of control.”

» Continue Reading

Bone marrow transplant may be answer to incurable, fatal blood disease

September 4, 2014 | by   

Even its name is daunting. Systemic mastocytosis is a fatal disease of the blood with no known cure. But a new study suggests a bone marrow transplant may be the answer for some patients.

Nakamura and Pullarkat

Systemic mastocytosis is currently considered a fatal blood disorder. City of Hope researchers Ryotaro Nakamura, left, and Vinod Pullarkat have found that bone marrow transplantation could offer a cure.

While rare, systemic mastocytosis is resistant to treatment with drugs and, when aggressive, can be fatal within four years of diagnosis. No standard therapy currently exists for the disease, which is caused by an overabundance of mast cells in the blood and bone marrow.

Mast cells are a type of white blood cell that normally helps in wound healing and in defending against infectious disease agents. The cells also are involved in allergic reactions including anaphylaxis, a severe reaction that can sometimes lead to death.

Patients with mastocytosis tend to develop hives and itching and are prone to anaphylactic shock. They also can develop other blood cancers such as leukemia and myelodysplasia together with systemic mastocytosis. » Continue Reading

High-fat diet? You are what you eat, right down to your DNA

September 3, 2014 | by   

Could what you eat affect the health of your chromosomes? The short answer is, “Yes.”

Rama Natarajan and Dustin Schones

A high-fat diet may lead to detrimental changes to your chromosomes say Rama Natarajan, left, and Dustin Schones.

Researchers led by Dustin Schones, Ph.D., assistant professor in the Department of Cancer Biology, and Rama Natarajan, Ph.D., director of the Division of Molecular Diabetes Research and the National Business Products Industry Professor in Diabetes Research, have found that a high-fat diet can lead to chemical changes in chromatin, the bundles of DNA and protein that form chromosomes. Further, the team found that those changes to chromatin structure can, in fact, alter the way genes are expressed in cells.

Researchers have long known that diet is a key factor leading to metabolic diseases such as type 2 diabetes. These disorders result in abnormal processing of fats, proteins, sugars and other important molecules in the body.

» Continue Reading