Oral cancer patient, 25, now urges others: Demand answers to symptoms

December 15, 2014 | by   

When 25-year-old Angelina Mattos was diagnosed with Stage 4 oral cancer earlier this year, she learned that her only hope of survival was through the removal of her tongue, a surgery that leaves people without the ability to talk or eat normally, sometimes permanently ending their ability to speak.

Tounge cancer patient Angie Mattos

Tongue cancer incidence rates are increasing in women ages 18 to 44. Angelina Mattos, right, was initially misdiagnosed; now she urges people with symptoms to be their own advocates. She’s shown here with Ellie Maghami, chief of head and neck surgery at City of Hope, who warns that oral cancers are best diagnosed early.

After hearing the prognosis, her family wanted to record Mattos so they could still listen to her voice when she could no longer talk. They suggested she record herself reading children’s books in case she ultimately decided to have children.

But Mattos wouldn’t let them. She refused to let her family, or herself, believe she would never again speak. She decided that she would beat the odds, that she would indeed regain her ability to talk. (Watch her recent interview with CBS.)

That decision was a defining moment in the Pomona woman’s long, and unexpected, battle with oral cancer.

» Continue Reading

Mother gets stem cells from brother; her son donates to stranger. Karma?

December 12, 2014 | by   

Two years ago, Joselyn Miller and her family sat together as stem cells from her brother’s bone marrow were infused into her – a precious gift of life that the family is excited to have the chance to pass to another patient in need.

cancer survivor and bone marrow recipient Joselyn Miller

Stem cell recipient Joselyn Miller and her brother, Leason Pomeroy, who donated bone marrow to her for a lifesaving transplant, pose for a photo at the Bone Marrow Transplant Reunion at City of Hope.

Today, the stem cell recipient is healthy. Her 23-year-old son Rex, who joined Be the Match’s bone marrow registry during the Bone Marrow Transplant Reunion in support of his mother, has had a rare opportunity: He was found to be an ideal match for a 65-year-old man abroad who needed a stem cell transplant.

Rex donated stem cells at City of Hope on Nov. 18 – nearly two years to the day from his mother’s own bone marrow transplant. » Continue Reading

Tongue cancer is increasing; 5 ways to reduce your risk

December 11, 2014 | by   

Even as the overall rate of oral cancers in the United States steadily declines, the rate of tongue cancer is increasing — especially among white females ages 18 to 44.

screening for oral cancers.

Tongue cancer incidence rates are increasing among white females ages 18 to 44, even those who don’t  smoke. Ellie Maghami gives advice how to lower your risk.

An oral cancer diagnosis, although rare, is serious. Only half of the people diagnosed with oral cancer are still alive after five years, according to the federal Centers for Disease Control and Prevention. In large part, that’s because of the late diagnoses of this disease. Early signs of this cancer in young adults can be easily overlooked by primary physicians.

Although the reason for the rise among young adults is unclear, people can take steps to reduce their risk of serious disease, especially a late-stage diagnosis.

Ellie Maghami, M.D., chief of head and neck surgery at City of Hope, offers this advice: » Continue Reading

Lung metastasis isn’t the same as lung cancer. Know the difference

December 10, 2014 | by   

lungsSometimes cancer found in the lungs is not lung cancer at all. It can be another type of cancer that originated elsewhere in the body and spread, or metastasized, to the lungs through the bloodstream or lymphatic system. These tumors are called lung metastases, or metastatic cancer to the lungs, and are not the same as lung cancer or even metastatic lung cancer.

Metastatic lung cancer originates in the lungs, but then spreads. It happens when cancer cells break away from the lungs and travel to other parts of the body, such as the brain or breasts. (Even though a cancerous growth may have formed in a different location, it is still named after the part of the body where it started.)

Lung metastases are different, and treatment of them requires a thorough understanding of the various types of lung tumors. Unfortunately, almost any cancer can metastasize to the lungs and initiate a lung metastasis. The most common cancers include bladder cancer, breast cancer, colon cancer, kidney cancer, prostate cancer, neuroblastoma, Wilm’s tumor and sarcoma. There’s no way around it – a lung metastasis is a serious, life-threatening condition that is difficult to treat successfully, although some patients may gain years through surgical removal of the tumor. » Continue Reading

City of Hope research advances treatment of hematologic cancers

December 9, 2014 | by   

When it comes to research into the treatment of hematologic cancers, City of Hope scientists stand out. One study that  they presented this week at the annual meeting of the American Society of Hematology suggests a new standard of care for HIV-associated lymphoma, another offers promise for the treatment of relapsing or treatment-resistant lymphoma, and still another points to more effective treatment for acute lymphoblastic leukemia.

Research into hematologic cancers

City of Hope research presented at the American Society of Hematology meetings provides promising new data for the treatment of hematologic cancers.

Researchers from the Hematologic Malignancies and Stem Cell Transplantation Institute at City of Hope shared their findings at the annual ASH meeting, held Dec. 6 through 9, in San Francisco. More than 20,000 hematology professionals attended the annual conference, which highlights the hottest topics in the field.

Here are some of the highlights: » Continue Reading

Stem cell transplants OK for HIV-linked lymphoma patients, study finds

December 8, 2014 | by   

Patients with HIV-associated lymphoma may soon have increased access to the current standard of care for some non-HIV infected patients – autologous stem cell transplants.

Joseph Alvarnas

City of Hope’s Joseph Alvarnas shares results from a City of Hope study at the annual ASH meeting that supports change to standard of care for HIV lymphoma.

Impressive new data, presented Monday at the annual meeting of the American Society of Hematology (ASH) in San Francisco, indicate that HIV-associated lymphoma patients who meet standard eligibility criteria for transplants of their own stem cells respond well to the treatment, even in centers that do not have HIV-specific expertise. HIV infection has historically been viewed as reason to rule out autologous stem cell transplant – the standard of care for non-infected patients with relapsed or treatment-resistant lymphoma – due to their compromised immune system.

The new study could change that perception. It was led by Joseph Alvarnas, M.D., director of Medical Quality and Quality, Risk and Regulatory Management and a physician investigator at the Hematologic Malignancies and Stem Cell Transplantation Institute at City of Hope, and colleagues at Johns Hopkins Hospital. The study builds on previous research at City of Hope, including a crucial 2001 publication that was among the first internationally to show these transplants were possible for HIV patients. » Continue Reading

Inspiring Stories: In Rose Parade, couple celebrates love and 2 triumphs

December 8, 2014 | by   

On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the Rose Parade is “Inspiring Stories.”

By Evan Braggs

Evan Bragg and Melina Fregoso were first friends, now soul mates. And they're grateful to City of Hope  for the care that helped them overcome cancer.

Evan Braggs and Melina Fregoso were first friends, now soul mates. And they credit City of Hope for giving them a future beyond cancer. On New Year’s Day, they will ride the City of Hope Rose Parade float together. (Photo Courtesy of Evan Braggs)

City of Hope is a place of just that, “a City of Hope.”

It was June of 2004, when I became a patient at City of Hope. At the age of 19, I was diagnosed with a rare blood disease called aplastic anemia. Not having had as much as a broken bone or a need for any type of surgery, I had to be cursed with a blood disorder, I thought.

What I labeled as a curse turned out to be the most humbling experience and lesson I’ve learned to this day. I was blessed to have the opportunity to meet a City filled with wonderful and extraordinary people who, in some cases, have influenced some of my adulthood decisions.

City of Hope has provided me with not just a second chance at life, but much more than that. After receiving a successful bone marrow transplant in June of 2005 from an unrelated donor, I had a different outlook on life. » Continue Reading

Need gift ideas for kids and teens in the hospital? Try these

December 8, 2014 | by   

The holidays can create an overwhelming urge to give to people in need — especially to sick children and families spending the holidays in a hospital room.

That’s a good thing. Holiday donations of toys and gifts can bolster the spirits, and improve the lives, of people affected by illness, and hospitals nationwide rely on the generosity of the public to help provide holiday cheer.

“Sometimes even the smallest gestures can mean the world to someone going through a difficult time,” said Renee Ortiz, L.C.S.W., a pediatric social worker at City of Hope.

But before scouring the shelves at the local mall, give some thought to what pediatric patients and their families actually want and need. The No. 1 item on children’s and young adults’ wish lists? Gift cards.

“Gift cards allow patients and their families to shop in many ways,” Ortiz said. “They can go to the store and pick out what they need. And for patients who are stuck in the hospital during the holiday season, they can shop online. It allows them to shop and look forward for their items to be delivered to them.”

Other popular gifts include educational toys, arts and craft kits, and movies. Check out the City of Hope website for a full list of gift ideas for kids, teens and young adults.

But one more thing … If you’re finding it hard to resist that adorable stuffed animal, try a little harder. At City of Hope, stuffed animals and plush toys are strongly discouraged. A number of patients suffer from weakened immune systems, and these toys can easily trap dust and other substances that can potentially make the children even sicker.

If you want to make your donation in person, call City of Hope’s Department of Pediatrics at 626-256,4673, ext. 65430.  The team will arrange for a time to meet you and accept the gifts on behalf of City of Hope patients. The deadline for holiday donations is Dec. 19. If you would like to make a monetary donation, please include a note clearly explaining the purpose of the gift, e.g., a donation to the Department of Pediatrics for pediatric patient gifts, activities, etc. 




Inspiring Stories: I faced cancer at 29, breast cancer survivor says

December 7, 2014 | by   

On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.”

Here, Melina Fregoso shares her story.

Natalia "Melina" Fregoso, breast cancer survivor at City of Hope

Natalia “Melina” Fregoso, pictured at a beauty event for City of Hope patients last March while she was undergoing treatment for breast cancer, will ride atop the 2015 City of Hope Rose Parade float.

By Natalia “Melina” Fregoso

2014 has been a year full of changes in my life. I went from being very healthy to being diagnosed with breast cancer. I went from having long hair to being completely bald. I went from being single to being with the man I have always prayed for. And I left my twenties and turned the big 3-0!

Last December, after a great morning workout, I was taking a shower when I felt a lump on my left breast. I didn’t wait a single minute to go to the doctor. I started 2014 undergoing a mammogram and an ultrasound, and then a biopsy later in the month. On Jan. 23 was when I heard, “You have cancer.”

I was scared, but relaxed. I was 29 years old and I had breast cancer. I went to the car, and I started crying, while praying to God for strength and something positive to come out of this situation. » Continue Reading

Made in City of Hope: Drug stops cancer’s siren call to the immune system

December 5, 2014 | by   

Cancer has a way of “talking” to the immune system and corrupting it to work on its own behalf instead of defending the body. Blocking this communication would allow the immune system to see cancer cells for what they are – something to be fought off – and stop them from growing.

Hua Yu, Ph.D, and her lab team

At City of Hope, Hua Yu and her team developed a drug that will clamp down on STAT3, halting its ability to talk to the immune system.

A breakthrough

Scientists have known for some time that cancer uses a protein called STAT3 to talk to the immune system. At City of Hope, Hua Yu, Ph.D, the Billy and Audrey L. Wilder Professor in Tumor Immunotherapy, and her team sought more than simply an understanding of how the two are able to connect and communicate. They wanted to create a treatment to address it.

Based on what they discovered about how STAT3 works, Yu and her team developed a drug that would clamp down on STAT3, halting its ability to talk to the immune system. Known as CpG-STAT3 siRNA, the drug administers a dual blow: It blocks the growth of cancer cells, even as it sends a message to surrounding immune cells to destroy the tumor. CpG-STAT3 siRNA also appears to enhance the effectiveness of other immunotherapies, such as T cell therapy, by helping prevent cancer from subverting the immune system.

» Continue Reading